The Genomic Architecture of Novel <i>Simulium damnosum Wolbachia</i> Prophage Sequence Elements and Implications for Onchocerciasis Epidemiology.

ABSTRACT: Research interest in Wolbachia is growing as new discoveries and technical advancements reveal the public health importance of both naturally occurring and artificial infections. Improved understanding of the Wolbachia bacteriophages (WOs) WOcauB2 and WOcauB3 [belonging to a sub-group of four WOs encoding serine recombinases group 1 (sr1WOs)], has enhanced the prospect of novel tools for the genetic manipulation of Wolbachia. The basic biology of sr1WOs, including host range and mode of genomic integration is, however, still poorly understood. Very few sr1WOs have been described, with two such elements putatively resulting from integrations at the same Wolbachia genome loci, about 2 kb downstream from the FtsZ cell-division gene. Here, we characterize the

SUBMITTER: Crainey JL 

PROVIDER: S-EPMC5447182 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature