The Effect of Botulinum Toxin A on Ischemia-Reperfusion Injury in a Rat Model.

ABSTRACT:

Introduction

While studies using various materials to overcome ischemia-reperfusion (IR) injury are becoming increasingly common, studies on the effects of botulinum toxin A (BoTA) on IR injury in musculocutaneous flaps are still limited. The purpose of this study was to examine our hypotheses that BoTA provide protection of musculocutaneous flap from ischemia-reperfusion injury.

Method

Five days after pretreatment injection (BoTA versus normal saline), a right superior musculocutaneous flap (6 × 1.5 cm in size) was made. Ischemia was created by a tourniquet strictly wrapping the pedicle containing skin and muscle for 8 h. After ischemia, the tourniquet was cut, and the musculocutaneous flap was reperfused.

Results

The overall survival percentage of flap after 8 h of

SUBMITTER: Park TH 

PROVIDER: S-EPMC5447266 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature