The Significant Pathways and Genes Underlying the Colon Cancer Treatment by the Traditional Chinese Medicine PHY906.

ABSTRACT:

Background

We attempted to explore the molecular mechanism underlying PHY906 intervention of colon cancer.

Methods

The microarray data of tumors treated by PHY906 and PBS alone were downloaded from the public Gene Expression Omnibus database. The dataset was further analyzed for the differentially expressed genes (DEGs) and their related biological functions were analyzed, followed by function and pathways. Protein-protein interaction (PPI) network was constructed and the significant nodes were screened by network centralities and then the significant modules analysis. Besides, they were clustered and transcriptional factors (TFs) were predicted.

Results

The gene expression patterns changed induced by PHY906 treatment, including 414 upregulated and 337 downregulated D

SUBMITTER: Su Z 

PROVIDER: S-EPMC5447272 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature