Genome-Wide Estimates of Transposable Element Insertion and Deletion Rates in Drosophila Melanogaster.

ABSTRACT: Knowing the rate at which transposable elements (TEs) insert and delete is critical for understanding their role in genome evolution. We estimated spontaneous rates of insertion and deletion for all known, active TE superfamilies present in a set of Drosophila melanogaster mutation-accumulation (MA) lines using whole genome sequence data. Our results demonstrate that TE insertions far outpace TE deletions in D. melanogaster. We found a significant effect of background genotype on TE activity, with higher rates of insertions in one MA line. We also found significant rate heterogeneity between the chromosomes, with both insertion and deletion rates elevated on the X relative to the autosomes. Further, we identified significant associations between TE activity and chromatin state, and tested

SUBMITTER: Adrion JR 

PROVIDER: S-EPMC5447328 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature