BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.

ABSTRACT:

Objective

To examine the influence of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on longitudinal cognitive trajectories in a large, cognitively healthy cohort enriched for Alzheimer disease (AD) risk and to understand whether β-amyloid (Aβ) burden plays a moderating role in this relationship.

Methods

One thousand twenty-three adults (baseline age 54.94 ± 6.41 years) enrolled in the Wisconsin Registry for Alzheimer's Prevention underwent BDNF genotyping and cognitive assessment at up to 5 time points (average follow-up 6.92 ± 3.22 years). A subset (n = 140) underwent ¹¹C-Pittsburgh compound B (PiB) scanning. Covariate-adjusted mixed-effects regression models were used to elucidate the effect of BDNF on cognitive trajecto

SUBMITTER: Boots EA 

PROVIDER: S-EPMC5447398 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature