Space and location of cerebral microbleeds, cognitive decline, and dementia in the community.

ABSTRACT:

Objective

To assess the association of the number and anatomic location of cerebral microbleeds (CMBs), visible indicators of microvascular damage on MRI, with incident cognitive disease in the general population of older people.

Methods

In the longitudinal population-based Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, 2,602 participants 66 to 93 years of age and free of prevalent dementia underwent brain MRI and cognitive testing of verbal memory, processing speed, and executive function at baseline and a mean of 5.2 years later. Adjudicated incident dementia cases were diagnosed according to international guidelines.

Results

In the multiple linear regression models adjusted for demographic, genetic, cardiovascular risk, and other cerebrovascular MRI m

SUBMITTER: Ding J 

PROVIDER: S-EPMC5447401 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature