Improving the Resolution of Kendrick Mass Defect Analysis for Polymer Ions with Fractional Base Units.

ABSTRACT: The concept of a fractional base unit for the Kendrick mass defect (KMD) analysis of polymer ions is introduced for the first time. A fraction of the ethylene oxide (EO) repeat unit (namely EO/8) has been used for the KMD analysis of a poly(ethylene oxide) and found to amplify the variations of KMD between monoisotopic and ¹³C isotopes, producing an isotopically resolved KMD plot at full scale when the KMD plot computed with EO is fuzzy. The expansion of the KMD dimension using a fractional base unit has then been successfully used to unequivocally discriminate all the distributions from a blend of poly(ethylene oxide)s in a high resolution KMD plot calculated with EO/3 as base unit. Extending the concept of fractional base units to other repeat units, the visualization of the c

SUBMITTER: Fouquet T 

PROVIDER: S-EPMC5447562 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature