Molecular Signatures of Human Regulatory T Cells in Colorectal Cancer and Polyps.

ABSTRACT: Regulatory T cells (Tregs), a subset of CD4⁺ or CD8⁺ T cells, play a pivotal role in regulating immune homeostasis. An increase in Tregs was reported in many tumors to be associated with immune suppression and evasion in cancer patients. Despite the importance of Tregs, the molecular signatures that contributed to their pathophysiological relevance remain poorly understood and controversial. In this study, we explored the gene expression profiles in Tregs derived from patients with colorectal cancer [colorectal carcinoma (CRC), n = 15], colorectal polyps (P, n = 15), and in healthy volunteers (N, n = 15). Tregs were analyzed using CD4⁺CD25⁺CD127^lowFoxP3⁺ antibody markers. Gene expression profiling analys

SUBMITTER: Johdi NA 

PROVIDER: S-EPMC5447675 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature