Differential Functional Connectivity Alterations of Two Subdivisions within the Right dlPFC in Parkinson's Disease.

ABSTRACT: Patients suffering from Parkinson's disease (PD) often show impairments in executive function (EF) like decision-making and action control. The right dorsolateral prefrontal cortex (dlPFC) has been strongly implicated in EF in healthy subjects and has repeatedly been reported to show alterations related to EF impairment in PD. Recently, two key regions for cognitive action control have been identified within the right dlPFC by co-activation based parcellation. While the posterior region is engaged in rather basal EF like stimulus integration and working memory, the anterior region has a more abstract, supervisory function. To investigate whether these functionally distinct subdivisions of right dlPFC are differentially affected in PD, we analyzed resting-state functional connectivity (FC)

SUBMITTER: Caspers J 

PROVIDER: S-EPMC5447710 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature