The Incremental Value of Repeated Induced Sputum and Gastric Aspirate Samples for the Diagnosis of Pulmonary Tuberculosis in Young Children With Acute Community-Acquired Pneumonia.

ABSTRACT:

Background.

Mycobacterium tuberculosis (Mtb) contributes to the pathogenesis of childhood acute community-acquired pneumonia in settings with a high tuberculosis burden. The incremental value of a repeated induced sputum (IS) sample, compared with a single IS or gastric aspirate (GA) sample, is not well known.

Methods.

Two IS samples were obtained for Mtb culture from children enrolled as cases in the Pneumonia Etiology Research for Child Health (PERCH) study in South Africa. Nonstudy attending physicians requested GA if pulmonary tuberculosis was clinically suspected. We compared the Mtb yield of 2 IS samples to that of 1 IS sample and GA samples.

Results

. Twenty-seven (3.0%) culture-confirmed pulmonary tuberculosis cases were identified among 906 children investiga

SUBMITTER: Moore DP 

PROVIDER: S-EPMC5447846 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature