Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring.

ABSTRACT:

Background

Mice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans.

Objective

We aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness (BHR), and total and specific IgEs, measured before conception vs. after birth, with offspring asthma and hayfever.

Methods

The study included 4293 participants (mean age 34, 47% men) from the European Community Respiratory Health Survey (ECRHS) with information on asthma symptom severity, BHR, total and specific IgEs from 1991 to 1993, and data on 9100 offspring born 1972-2012. Adjusted relative risk ratios (aRRR) for associations of paren

SUBMITTER: Bertelsen RJ 

PROVIDER: S-EPMC5447870 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature