Variability of DNA Methylation within Schizophrenia Risk Loci across Subregions of Human Hippocampus.

ABSTRACT: Identification of 108 genomic regions significantly associated with schizophrenia risk by the Psychiatric Genomics Consortium was a milestone for the field, and much work is now focused on determining the mechanism of risk associated with each locus. Within these regions, we investigated variability of DNA methylation, a low-level cellular phenotype closely linked to genotype, in two highly similar cellular populations sampled from the human hippocampus, to draw inferences about the elaboration of genotype to phenotype within these loci enriched for schizophrenia risk. DNA methylation was assessed with the Illumina HumanMethylation450 BeadArray in tissue laser-microdissected from the stratum oriens of subfield CA1 or CA2/3, regions having unique connectivity with intrinsic and extrinsic fi

SUBMITTER: Ruzicka WB 

PROVIDER: S-EPMC5448017 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature