Activated Platelets Induce an Anti-Inflammatory Response of Monocytes/Macrophages through Cross-Regulation of PGE₂ and Cytokines.

ABSTRACT: Platelets are well known for their role in hemostasis and are also increasingly recognized for their roles in the innate immune system during inflammation and their regulation of macrophage activation. Here, we aimed to study the influence of platelets on the production of inflammatory mediators by monocytes and macrophages. Analyzing cocultures of platelets and murine bone marrow-derived macrophages or human monocytes, we found that collagen-activated platelets release high amounts of prostaglandin E₂ (PGE₂) that leads to an increased interleukin- (IL-) 10 release and a decreased tumor necrosis factor (TNF) α secretion out of the monocytes or macrophages. Platelet PGE₂ mediated the upregulation of IL-10 in both cell types via the PGE₂ rec

SUBMITTER: Linke B 

PROVIDER: S-EPMC5448075 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature