Mapping Interpuff Interval Distribution to the Properties of Inositol Trisphosphate Receptors.

ABSTRACT: Tightly clustered inositol trisphosphate receptors (IP₃Rs) control localized Ca²⁺ liberation from the endoplasmic reticulum to generate repetitive Ca²⁺ puffs. Distributions of the interpuff interval (IPI), i.e., the waiting time between successive puffs, are found to be well characterized by a probability density function involving only two parameters, λ and ξ, which represent the basal rate of puff generation and the recovery rate from refractoriness, respectively. However, how the two parameters depend on the kinetic parameters of single IP₃Rs in a cluster is still unclear. In this article, using a stochastic puff model and a single-channel data-based IP₃R model, we establish the dependencies of λ and ξ on two important IP₃

SUBMITTER: Cao P 

PROVIDER: S-EPMC5448242 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature