Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study.

ABSTRACT:

Objectives

The Protocol-based Care for Early Septic Shock trial found no differences across alternative resuscitation strategies in all-cause mortality. A separate aim was to determine whether differences in resuscitation strategies affected trajectories of biomarkers of key pathways associated with downstream clinical outcomes of sepsis and whether there were differences in survival across treatment arms for patients with different baseline biomarker profiles.

Design

Secondary analysis of a large randomized clinical trial.

Setting

Thirty-one U.S. hospitals.

Patients

Six hundred twenty-eight patients with septic shock.

Interventions

Two resuscitation protocols versus usual care.

Measurements and main results

We measured a panel of biomarkers repre

SUBMITTER: Kellum JA 

PROVIDER: S-EPMC5448291 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature