Identification of a three-gene expression signature of poor-prognosis breast carcinoma.

ABSTRACT:

Background

The clinical course of breast cancer is difficult to predict on the basis of established clinical and pathological prognostic criteria. Given the genetic complexity of breast carcinomas, it is not surprising that correlations with individual genetic abnormalities have also been disappointing. The use of gene expression profiles could result in more accurate and objective prognostication.

Results

To this end, we used real-time quantitative RT-PCR assays to quantify the mRNA expression of a large panel (n = 47) of genes previously identified as candidate prognostic molecular markers in a series of 100 ERalpha-positive breast tumor samples from patients with known long-term follow-up. We identified a three-gene expression signature (BRCA2, DNMT3B and CCNE1) as an ind

SUBMITTER: Bieche I 

PROVIDER: S-EPMC544833 | biostudies-literature | 2004 Dec

REPOSITORIES: biostudies-literature