Abnormal reward circuitry in anorexia nervosa: A longitudinal, multimodal MRI study.

ABSTRACT: Anorexia nervosa (AN) is a debilitating illness and existing interventions are only modestly effective. This study aimed to determine whether AN pathophysiology is associated with altered connections within fronto-accumbal circuitry subserving reward processing. Diffusion and resting-state functional MRI scans were collected in female inpatients with AN (n = 22) and healthy controls (HC; n = 18) between the ages of 16 and 25 years. Individuals with AN were scanned during the acute, underweight phase of the illness and again following inpatient weight restoration. HC were scanned twice over the same timeframe. Based on univariate and multivariate analyses of fronto-accumbal circuitry, underweight individuals with AN were found to have increased structural connectivity (diffusion probabilist

SUBMITTER: Cha J 

PROVIDER: S-EPMC5448464 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature