Spirometric predictors of lung function decline and mortality in early chronic obstructive pulmonary disease.

ABSTRACT:

Rationale

The course of lung function decline for smokers with early airflow obstruction remains undefined. It is also unclear which early spirometric characteristics identify individuals at risk for rapid decline and increased mortality.

Objectives

To determine the association between spirometric measures and 5-year decline in FEV(1) and 12-year mortality.

Methods

We analyzed longitudinal data from the Lung Health Study, a clinical trial of intensive smoking cessation intervention with or without bronchodilator therapy in 5,887 smokers with mild to moderate airflow obstruction. Participants were stratified into bins of baseline FEV(1) to FVC ratio, using bins of 5%, and separately into bins of Z-score (difference between actual and predicted FEV(1)/FVC, normalized to

SUBMITTER: Drummond MB 

PROVIDER: S-EPMC5448583 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature