Regulation of endothelial Fas expression as a mechanism of promotion of vascular integrity by mural cells in tumors.

ABSTRACT: Angiogenesis is a multi-step process that culminates in vascular maturation whereby nascent vessels stabilize to become functional, and mural cells play an essential role in this process. Recent studies have shown that mural cells in tumors also promote and maintain vascular integrity, with wide-reaching clinical implications including the regulation of tumor growth, metastases, and drug delivery. Various regulatory signaling pathways have been hitherto implicated, but whether regulation of Fas-dependent apoptotic mechanisms is involved has not yet been fully investigated. We first compared endothelial FAS staining in human pancreatic ductal adenocarcinomas and colon carcinomas and show that the latter, characterized by lower mural cell coverage of tumor vasculature, demonstrated higher ex

SUBMITTER: Kamei R 

PROVIDER: S-EPMC5448593 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature