Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.

ABSTRACT: Synthetic lethality and collateral lethality are two well-validated conceptual strategies for identifying therapeutic targets in cancers with tumour-suppressor gene deletions. Here, we explore an approach to identify potential synthetic-lethal interactions by screening mutually exclusive deletion patterns in cancer genomes. We sought to identify 'synthetic-essential' genes: those that are occasionally deleted in some cancers but are almost always retained in the context of a specific tumour-suppressor deficiency. We also posited that such synthetic-essential genes would be therapeutic targets in cancers that harbour specific tumour-suppressor deficiencies. In addition to known synthetic-lethal interactions, this approach uncovered the chromatin helicase DNA-binding factor CHD1 as a putativ

SUBMITTER: Zhao D 

PROVIDER: S-EPMC5448706 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature