The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants.

ABSTRACT:

Objectives

Studies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI).

Methods

We genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge.

Results

We found no association between MBL levels and sepsis risk in

SUBMITTER: Hartz A 

PROVIDER: S-EPMC5448758 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature