Kidney volume measurement methods for clinical studies on autosomal dominant polycystic kidney disease.

ABSTRACT:

Background

In autosomal dominant polycystic kidney disease (ADPKD), total kidney volume (TKV) is regarded as an important biomarker of disease progression and different methods are available to assess kidney volume. The purpose of this study was to identify the most efficient kidney volume computation method to be used in clinical studies evaluating the effectiveness of treatments on ADPKD progression.

Methods and findings

We measured single kidney volume (SKV) on two series of MR and CT images from clinical studies on ADPKD (experimental dataset) by two independent operators (expert and beginner), twice, using all of the available methods: polyline manual tracing (reference method), free-hand manual tracing, semi-automatic tracing, Stereology, Mid-slice and Ellipsoid method

SUBMITTER: Sharma K 

PROVIDER: S-EPMC5448775 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature