Gene duplication and co-evolution of G1/S transcription factor specificity in fungi are essential for optimizing cell fitness.

ABSTRACT: Transcriptional regulatory networks play a central role in optimizing cell survival. How DNA binding domains and cis-regulatory DNA binding sequences have co-evolved to allow the expansion of transcriptional networks and how this contributes to cellular fitness remains unclear. Here we experimentally explore how the complex G1/S transcriptional network evolved in the budding yeast Saccharomyces cerevisiae by examining different chimeric transcription factor (TF) complexes. Over 200 G1/S genes are regulated by either one of the two TF complexes, SBF and MBF, which bind to specific DNA binding sequences, SCB and MCB, respectively. The difference in size and complexity of the G1/S transcriptional network across yeast species makes it well suited to investigate how TF paralogs (SBF and MBF) an

SUBMITTER: Hendler A 

PROVIDER: S-EPMC5448814 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature