Multiple roles of Ulk4 in neurogenesis and brain function.

ABSTRACT: Neurogenesis is essential for proper brain formation and function, and abnormal neural proliferation is an underlying neuropathology of many brain disorders. Recent advances on adult neurogenesis demonstrate that neural stem cells (NSCs) at the subventricular zone (SVZ) are largely derived during mid-embryonic neurogenesis from a subset of cells, which slow down in their pace of cell division,¹ become quiescent cells and can be reactivated in need.² The NSCs at birth constitute the stem cell pool for both postnatal oligodendrogenesis³ and adult neurogenesis.^1,2 However, little is known about factors that control the size of NSC pool. The article published in Stem Cells on Jun 14, 2016 by Liu and colleagues described a member of the Unc-51-like se

SUBMITTER: Liu M 

PROVIDER: S-EPMC5449176 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature