Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children.

ABSTRACT:

Aim

To identify metabolic signatures in urine samples from healthy and inflammatory bowel disease (IBD) children.

Methods

We applied liquid chromatography and gas chromatography coupled to targeted mass spectrometry (MS)-based metabolite profiling to identify and quantify bile acids and host-gut microbial metabolites in urine samples collected from 21 pediatric IBD patients monitored three times over one year (baseline, 6 and 12 mo), and 27 age- and gender-matched healthy children.

Results

urinary metabolic profiles of IBD children differ significantly from healthy controls. Such metabolic differences encompass central energy metabolism, amino acids, bile acids and gut microbial metabolites. In particular, levels of pyroglutamic acid, glutamic acid, glycine and cystei

SUBMITTER: Martin FP 

PROVIDER: S-EPMC5449421 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature