Genome-Wide Search for Genes Required for Bifidobacterial Growth under Iron-Limitation.

ABSTRACT: Bacteria evolved over millennia in the presence of the vital micronutrient iron. Iron is involved in numerous processes within the cell and is essential for nearly all living organisms. The importance of iron to the survival of bacteria is obvious from the large variety of mechanisms by which iron may be acquired from the environment. Random mutagenesis and global gene expression profiling led to the identification of a number of genes, which are essential for Bifidobacterium breve UCC2003 survival under iron-restrictive conditions. These genes encode, among others, Fe-S cluster-associated proteins, a possible ferric iron reductase, a number of cell wall-associated proteins, and various DNA replication and repair proteins. In addition, our study identified several presumed iron upta

SUBMITTER: Lanigan N 

PROVIDER: S-EPMC5449479 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature