Trichinella spiralis Calreticulin Binds Human Complement C1q As an Immune Evasion Strategy.

ABSTRACT: As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing a variety of immunomodulatory molecules to escape from host immune attack, but the mechanisms underlying the immune evasion are not well understood. Here, we identified that T. spiralis calreticulin (Ts-CRT), a Ca²⁺-binding protein, facilitated T. spiralis immune evasion by interacting with the first component of human classical complement pathway, C1q. In the present study, Ts-CRT was found to be expressed on the surface of different developmental stages of T. spiralis as well as in the secreted products of adult and muscle larval worms. Functional analysis identified that Ts-CRT was able to bind to human C1q, resulting in the

SUBMITTER: Zhao L 

PROVIDER: S-EPMC5449505 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature