Expression of Class I and Class II a/b Histone Deacetylase is Dysregulated in Hypertensive Animal Models.

ABSTRACT:

Background and objectives

Dysregulation of histone deacetylase expression and enzymatic activity is associated with a number of diseases. It has been reported that protein levels of histone deacetylase (HDAC)1 and HDAC5 increase during human pulmonary hypertension, and that the enzymatic activity of HDAC6 is induced in a chronic hypertensive animal model. This study investigated the protein expression profiles of class I and II a/b HDACs in three systemic hypertension models.

Subjects and methods

We used three different hypertensive animal models: (i) Wistar-Kyoto rats (n=8) and spontaneously hypertensive rats (SHR; n=8), (ii) mice infused with saline or angiotensin II to induce hypertension, via osmotic mini-pump for 2 weeks, and (iii) mice that were allowed to drink L-N

SUBMITTER: Kee HJ 

PROVIDER: S-EPMC5449534 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature