DRNApred, fast sequence-based method that accurately predicts and discriminates DNA- and RNA-binding residues.

ABSTRACT: Protein-DNA and protein-RNA interactions are part of many diverse and essential cellular functions and yet most of them remain to be discovered and characterized. Recent research shows that sequence-based predictors of DNA-binding residues accurately find these residues but also cross-predict many RNA-binding residues as DNA-binding, and vice versa. Most of these methods are also relatively slow, prohibiting applications on the whole-genome scale. We describe a novel sequence-based method, DRNApred, which accurately and in high-throughput predicts and discriminates between DNA- and RNA-binding residues. DRNApred was designed using a new dataset with both DNA- and RNA-binding proteins, regression that penalizes cross-predictions, and a novel two-layered architecture. DRNApred outperforms st

SUBMITTER: Yan J 

PROVIDER: S-EPMC5449545 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature