BrainScope: interactive visual exploration of the spatial and temporal human brain transcriptome.

ABSTRACT: Spatial and temporal brain transcriptomics has recently emerged as an invaluable data source for molecular neuroscience. The complexity of such data poses considerable challenges for analysis and visualization. We present BrainScope: a web portal for fast, interactive visual exploration of the Allen Atlases of the adult and developing human brain transcriptome. Through a novel methodology to explore high-dimensional data (dual t-SNE), BrainScope enables the linked, all-in-one visualization of genes and samples across the whole brain and genome, and across developmental stages. We show that densities in t-SNE scatter plots of the spatial samples coincide with anatomical regions, and that densities in t-SNE scatter plots of the genes represent gene co-expression modules that are significantl

SUBMITTER: Huisman SMH 

PROVIDER: S-EPMC5449549 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature