Reduced reactive hyperemia may explain impaired flow-mediated dilation after on-pump cardiac surgery.

ABSTRACT: In previous studies, Flow Mediated Dilation (FMD) was used to study the effect of cardiac surgery on endothelial function. This study investigated the effect of on-pump cardiac surgery on FMD and reactive hyperemia. The FMD-response and reactive hyperemia were measured in 25 patients the morning before- and the first morning after cardiac surgery. Brachial artery diameter and blood flow were measured with ultrasound at baseline before 5 min occlusion of the blood flow to the forearm, and continuously for 3 min after release of the occlusion. An exponential wash-out model was fitted to the blood flow over time. Nineteen patients remained for final data analysis. Data are mean ± SEM The FMD response was reduced after surgery from 3.3 ± 0.5% to 1.4 ± 0.6% (P = 0.02). Max blood flow aft

SUBMITTER: Dedichen HH 

PROVIDER: S-EPMC5449560 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature