Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells.

ABSTRACT: Epigenetic mechanisms, including chromatin structure, chromatin dynamics and histone modifications play an important role for maintenance and differentiation of pluripotent embryonic stem cells. However, little is known about the molecular mechanisms of adult stem cell specification and differentiation. Here, we used intestinal stem cells (ISCs) as a model system to reveal the epigenetic changes coordinating gene expression programs during these processes. We found that two distinct epigenetic mechanisms participate in establishing the transcriptional program promoting ISC specification from embryonic progenitors. A large number of adult ISC signature genes are targets of repressive DNA methylation in embryonic intestinal epithelial progenitors. On the other hand, genes essential for embry

SUBMITTER: Kazakevych J 

PROVIDER: S-EPMC5449638 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature