Development of plant-produced protein body vaccine candidates for bluetongue virus.

ABSTRACT:

Background

Bluetongue is a disease of domestic and wild ruminants caused by bluetongue virus serotypes (BTV), which have caused serious outbreaks worldwide. Commercially available vaccines are live-attenuated or inactivated virus strains: these are effective, but there is the risk of reversion to virulence or reassortment with circulating strains for live virus, and residual live virus for the inactivated vaccines. The live-attenuated virus vaccines are not able to distinguish naturally infected animals from vaccinated animals (DIVA compliant). Recombinant vaccines are preferable to minimize the risks associated with these vaccines, and would also enable the development of candidate vaccines that are DIVA-compliant.

Results

In this study, two novel protein body (PB) plant-pr

SUBMITTER: van Zyl AR 

PROVIDER: S-EPMC5450216 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature