First-in-Human Imaging with 89Zr-Df-IAB2M Anti-PSMA Minibody in Patients with Metastatic Prostate Cancer: Pharmacokinetics, Biodistribution, Dosimetry, and Lesion Uptake.

ABSTRACT: We conducted a phase I dose-escalation study with ⁸⁹Zr-desferrioxamine-IAB2M (⁸⁹Zr-IAB2M), an anti-prostate-specific membrane antigen minibody, in patients with metastatic prostate cancer.

Methods

Patients received 185 MBq (5 mCi) of ⁸⁹Zr-IAB2M and Df-IAB2M at total mass doses of 10 (n = 6), 20 (n = 6), and 50 mg (n = 6). Whole-body and serum clearance, normal-organ and lesion uptake, and radiation absorbed dose were estimated, and the effect of mass escalation was analyzed.

Results

Eighteen patients were injected and scanned without side effects. Whole-body clearance was monoexponential, with a median biologic half-life of 215 h, whereas serum clearance showed biexponential kinetics, with a median biologic half-life of 3.7 (12.3%/L) and 33.8

SUBMITTER: Pandit-Taskar N 

PROVIDER: S-EPMC5450345 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature