Dissection of additive, dominance, and imprinting effects for production and reproduction traits in Holstein cattle.

ABSTRACT:

Background

Although genome-wide association and genomic selection studies have primarily focused on additive effects, dominance and imprinting effects play an important role in mammalian biology and development. The degree to which these non-additive genetic effects contribute to phenotypic variation and whether QTL acting in a non-additive manner can be detected in genetic association studies remain controversial.

Results

To empirically answer these questions, we analyzed a large cattle dataset that consisted of 42,701 genotyped Holstein cows with genotyped parents and phenotypic records for eight production and reproduction traits. SNP genotypes were phased in pedigree to determine the parent-of-origin of alleles, and a three-component GREML was applied to obtain variance

SUBMITTER: Jiang J 

PROVIDER: S-EPMC5450346 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature