α- Versus β-Emitting Radionuclides for Pretargeted Radioimmunotherapy of Carcinoembryonic Antigen-Expressing Human Colon Cancer Xenografts.

ABSTRACT: Pretargeted radioimmunotherapy (PRIT) with the β-emitting radionuclide ¹⁷⁷Lu is an attractive approach to treat carcinoembryonic antigen (CEA)-expressing tumors. The therapeutic efficacy of PRIT might be improved using α-emitting radionuclides such as ²¹³Bi. Herein, we report and compare the tumor-targeting properties and therapeutic efficacy of ²¹³Bi and ¹⁷⁷Lu for PRIT of CEA-expressing xenografts, using the bispecific monoclonal antibody TF2 (anti-CEA × anti-histamine-succinyl-glycine [HSG]) and the di-HSG-DOTA peptide IMP288. Methods: The in vitro binding characteristics of ²¹³Bi-IMP288 were compared with those of ¹⁷⁷Lu-IMP288. Tumor targeting of ²¹³Bi-IMP288 and ¹⁷⁷Lu-IMP288 was studied in mi

SUBMITTER: Heskamp S 

PROVIDER: S-EPMC5450366 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature