Semiquantitative Parameters in PSMA-Targeted PET Imaging with ¹⁸F-DCFPyL: Variability in Normal-Organ Uptake.

ABSTRACT: ¹⁸F-DCFPyL is a small-molecule inhibitor of the prostate-specific membrane antigen that has shown promise for evaluation of primary and metastatic prostate cancer using PET. Measuring the variability in normal-organ uptake of ¹⁸F-DCFPyL is necessary to understand its biodistribution, aid image interpretation, judge the reliability of scan quantification, and provide a basis for therapeutic monitoring. Methods: Sixty-five consecutive ¹⁸F-DCFPyL PET/CT scans from 64 patients with a history of prostate cancer were analyzed. Volumes of interest were defined for the lacrimal glands, major salivary glands, liver, spleen, and both kidneys. The mean SUV normalized to body mass or to lean body mass (SUL) was calculated for each volume of interest. The average

SUBMITTER: Li X 

PROVIDER: S-EPMC5450367 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature