Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8.

ABSTRACT:

Background

Apoe-deficient (Apoe^-/-) mice develop progressive atherosclerotic lesions with age but no severe renal pathology in the absence of additional challenges. We recently described accelerated atherosclerosis as well as marked renal injury in Apoe^-/- mice deficient in the mesenchymal integrin chain Itga8 (Itga8^-/-). Here, we used this Apoe^-/-, Itga8^-/- mouse model to investigate the sex differences in the development of atherosclerosis and concomitant renal injury. We hypothesized that aging female mice are protected from vascular and renal damage in this mouse model.

Methods

Apoe^-/- mice were backcrossed with Itga8^-/- mice. Mice w

SUBMITTER: Marek I 

PROVIDER: S-EPMC5450388 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature