The association between genetic polymorphisms of the interleukin-23 receptor gene and susceptibility to uveitis: a meta-analysis.

ABSTRACT:

Background

Uveitis is an eye inflammatory disease, which is sometimes associated with underlying systemic disease. Interleukin-23 plays an important role in autoimmune disease. The aim of this meta-analysis was to evaluate the association between the interleukin-23 receptor (IL-23R) and susceptibility to uveitis.

Methods

Published literature from PUBMED and EMBASE were retrieved. Seven studies were included in this meta-analysis, covering a total of 1309 cases of uveitis and 2400 controls. Meta-analyses were conducted on the associations between uveitisand rs7517847, rs17375018, and rs11209032 polymorphisms in the IL-23R gene.

Results

There were no significant associations between IL-23R polymorphisms and uveitis with regard to the following alleles: for G allele vs.

SUBMITTER: Jung JH 

PROVIDER: S-EPMC5450396 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature