Transcriptomic Profiling of High-Density Giardia Foci Encysting in the Murine Proximal Intestine.

ABSTRACT: Giardia is a highly prevalent, understudied protistan parasite causing significant diarrheal disease worldwide. Its life cycle consists of two stages: infectious cysts ingested from contaminated food or water sources, and motile trophozoites that colonize and attach to the gut epithelium, later encysting to form new cysts that are excreted into the environment. Current understanding of parasite physiology in the host is largely inferred from transcriptomic studies using Giardia grown axenically or in co-culture with mammalian cell lines. The dearth of information about the diversity of host-parasite interactions occurring within distinct regions of the gastrointestinal tract has been exacerbated by a lack of methods to directly and non-invasively interrogate disease progressi

SUBMITTER: Pham JK 

PROVIDER: S-EPMC5450421 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature