Interactome Mapping Guided by Tissue-Specific Phosphorylation in Age-Related Macular Degeneration.

ABSTRACT: The current study aims to determine the molecular mechanisms of age-related macular degeneration (AMD) using the phosphorylation network. Specifically, we examined novel biomarkers for oxidative stress by protein interaction mapping using in vitro and in vivo models that mimic the complex and progressive characteristics of AMD. We hypothesized that the early apoptotic reactions could be initiated by protein phosphorylation in region-dependent (peripheral retina vs. macular) and tissue-dependent (retinal pigment epithelium vs. retina) manner under chronic oxidative stress. The analysis of protein interactome and oxidative biomarkers showed the presence of tissue- and region-specific post-translational mechanisms that contribute to AMD progression and suggested new therapeutic

SUBMITTER: Sripathi SR 

PROVIDER: S-EPMC5450497 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature