Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma.

ABSTRACT:

Background and purpose

A constant relative biological effectiveness (RBE) is used for clinical proton therapy; however, experimental evidence indicates that RBE can vary. We analyzed pediatric ependymoma patients who received proton therapy to determine if areas of normal tissue damage indicated by post-treatment image changes were associated with increased biological dose effectiveness.

Material and methods

Fourteen of 34 children showed T2-FLAIR hyperintensity on post-treatment magnetic resonance (MR) images. We delineated regions of treatment-related change and calculated dose and linear energy transfer (LET) distributions with Monte Carlo. Voxel-level image change data were fit to a generalized linear model incorporating dose and LET. Cross-validation was used to determi

SUBMITTER: Peeler CR 

PROVIDER: S-EPMC5450501 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature