Identification of the miRNA-target gene regulatory network in intracranial aneurysm based on microarray expression data.

ABSTRACT: Intracranial aneurysm (IA) remains one of the most devastating neurological conditions. However, the pathophysiology of IA formation and rupture still remains unclear. The purpose of the present study was to identify the crucial microRNA (miRNA/miR) and genes involved in IAs and elucidate the mechanisms underlying the development of IAs. In the present study, novel miRNA regulation activities in IAs were investigated through the integration of public gene expression data of miRNA and mRNA using the Gene Expression Omnibus database, combined with bioinformatics prediction. A total of 15 differentially expressed miRNA and 1,447 differentially expressed mRNA between IAs and controls were identified. A number of miRNA-target gene pairs (770), whose expression levels were inversely correlated,

SUBMITTER: Wang K 

PROVIDER: S-EPMC5450516 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature