Photomodulation of bacterial growth and biofilm formation using carbohydrate-based surfactants.

ABSTRACT: Naturally occurring and synthetic carbohydrate amphiphiles have emerged as a promising class of antimicrobial and antiadhesive agents that act through a number of dynamic and often poorly understood mechanisms. In this paper, we provide the first report on the application of azobenzene trans-cis photoisomerization for effecting spatial and temporal control over bacterial growth and biofilm formation using carbohydrate-based surfactants. Photocontrollable surface tension studies and small angle neutron scattering (SANS) revealed the diverse geometries and dimensions of self-assemblies (micelles) made possible through variation of the head group and UV-visible light irradiation. Using these light-addressable amphiphiles, we demonstrate optical control over the antibacterial act

SUBMITTER: Hu Y 

PROVIDER: S-EPMC5450525 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature