Thielavins W-Z₇, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004.

ABSTRACT: Eleven new depsides-thielavins W-Z (1-4) and thielavins Z₁-Z₇ (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC₅₀ values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.

SUBMITTER: Han Z 

PROVIDER: S-EPMC5450534 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature