Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies.

ABSTRACT: Extensive transcriptional and ontogenetic diversity exists among normal tissue-resident macrophages, with unique transcriptional profiles endowing the cells with tissue-specific functions. However, it is unknown whether the origins of different macrophage populations affect their roles in malignancy. Given potential artifacts associated with irradiation-based lineage tracing, it remains unclear if bone-marrow-derived macrophages (BMDMs) are present in tumors of the brain, a tissue with no homeostatic involvement of BMDMs. Here, we employed multiple models of murine brain malignancy and genetic lineage tracing to demonstrate that BMDMs are abundant in primary and metastatic brain tumors. Our data indicate that distinct transcriptional networks in brain-resident microglia and recruited BMDMs

SUBMITTER: Bowman RL 

PROVIDER: S-EPMC5450644 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature