Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood.

ABSTRACT: The in vivo origin of bone-producing osteoblasts is not fully defined. Skeletal stem cells, a population of mesenchymal stem cells resident in the bone marrow compartment, are thought to act as osteoprogenitors during growth and adulthood. Quiescent bone lining cells (BLCs) have been suggested as a population capable of activation into mature osteoblasts. These cells were defined by location and their morphology and studies addressing their significance have been hampered by their inaccessibility, and lack of markers that would allow for their identification and tracing. Using lineage tracing models, we have observed labeled osteoblasts at time points extending beyond the reported lifespan for this cell type, suggesting continuous reactivation of BLCs. BLCs also make a major contribution t

SUBMITTER: Matic I 

PROVIDER: S-EPMC5450652 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature