Image Guided Radiation Therapy Using Synthetic Computed Tomography Images in Brain Cancer.

ABSTRACT:

Purpose

The development of synthetic computed tomography (CT) (synCT) derived from magnetic resonance (MR) images supports MR-only treatment planning. We evaluated the accuracy of synCT and synCT-generated digitally reconstructed radiographs (DRRs) relative to CT and determined their performance for image guided radiation therapy (IGRT).

Methods and materials

Magnetic resonance simulation (MR-SIM) and CT simulation (CT-SIM) images were acquired of an anthropomorphic skull phantom and 12 patient brain cancer cases. SynCTs were generated using fluid attenuation inversion recovery, ultrashort echo time, and Dixon data sets through a voxel-based weighted summation of 5 tissue classifications. The DRRs were generated from the phantom synCT, and geometric fidelity was assessed rel

SUBMITTER: Price RG 

PROVIDER: S-EPMC5450663 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature