Dynamics of blood flow and thrombus formation in a multi-bypass microfluidic ladder network.

ABSTRACT: The reaction dynamics of a complex mixture of cells and proteins, such as blood, in branched circulatory networks within the human microvasculature or extravascular therapeutic devices such as extracorporeal oxygenation machine (ECMO) remains ill-defined. In this report we utilize a multi-bypass microfluidics ladder network design with dimensions mimicking venules to study patterns of blood platelet aggregation and fibrin formation under complex shear. Complex blood fluid dynamics within multi-bypass networks under flow were modeled using COMSOL. Red blood cells and platelets were assumed to be non-interacting spherical particles transported by the bulk fluid flow, and convection of the activated coagulation factor II, thrombin, was assumed to be governed by mass transfer. This model serve

SUBMITTER: Zilberman-Rudenko J 

PROVIDER: S-EPMC5450919 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature