Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial.

ABSTRACT:

Importance

Management of acute respiratory distress syndrome (ARDS) remains largely supportive. Whether early intervention can prevent development of ARDS remains unclear.

Objective

To evaluate the efficacy and safety of early aspirin administration for the prevention of ARDS.

Design, setting, and participants

A multicenter, double-blind, placebo-controlled, randomized clinical trial conducted at 16 US academic hospitals. Between January 2, 2012, and November 17, 2014, 7673 patients at risk for ARDS (Lung Injury Prediction Score ≥4) in the emergency department were screened and 400 were randomized. Ten patients were excluded, leaving 390 in the final modified intention-to-treat analysis cohort.

Interventions

Administration of aspirin, 325-mg loading dose follow

SUBMITTER: Kor DJ 

PROVIDER: S-EPMC5450939 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature